LymphedemaV1, Main, Exploration, bibRecord, 00E058

Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher‐grade sarcomas

Identifieur interne : 00E058 ( Main/Exploration ); précédent : 00E057; suivant : 00E059

Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher‐grade sarcomas

Auteurs : Ernest E. Lack [États-Unis] ; Seth M. Steinberg [États-Unis] ; Donald E. White [États-Unis] ; Timothy Kinsella [États-Unis] ; Eli Glatstein [États-Unis] ; Alfred E. Chang [États-Unis] ; Steven A. Rosenberg [États-Unis]

Source :

Journal of Surgical Oncology [ 0022-4790 ] ; 1989-08.

RBID : ISTEX:37FEB04A8699AD294B719A83B9D507B853B39207

Abstract

From July 1975 to February 1985, 300 patients with extremity soft tissue sarcomas (STS) were entered into treatment protocols at the National Cancer Institute. Using the Cox proportional hazards model, the STS were analyzed for independent prognostic variables that had significant association with disease‐free and overall survival. The effects of adjuvant treatment were also included in the analysis. Percent tumor necrosis was the basis for separating intermediate and high‐grade STS (< 15% necrosis = grade 2; > 15% necrosis = grade 3). The most important prognostic variable was histologic grade, which was highly associated with relative risk of metastasis and fatal outcome (P < .0001). Histologic type of STS was not a significant prognostic variable in predicting metastases. Patients with tumors located on the proximal or middle part of the extremity had a fivefold increased risk of death (P = .02) compared with patients who had STS located more distally. Mitotic activity (P = .0005) and vascular invasion (P = .0034) were also associated with malignant behavior, but histologic grade was the most significant predictor of outcome. Histologic grade of malignancy was based upon a combination of tumor typing and visual estimation of extent of tumor necrosis; using these two features, one can reliably separate low‐grade (i.e., grade 1) from high‐grade STS and also stratify the more aggressive (i.e., grade 2 and 3) tumors. Over the 9.5‐year period of study, the tumor‐related mortality was as follows: grade 1 (1/38), 3%; grade 2 (19/142), 13%; and grade 3 (45/120), 38%.

Url:

https://api.istex.fr/document/37FEB04A8699AD294B719A83B9D507B853B39207/fulltext/pdf

DOI: 10.1002/jso.2930410414

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">From July 1975 to February 1985, 300 patients with extremity soft tissue sarcomas (STS) were entered into treatment protocols at the National Cancer Institute. Using the Cox proportional hazards model, the STS were analyzed for independent prognostic variables that had significant association with disease‐free and overall survival. The effects of adjuvant treatment were also included in the analysis. Percent tumor necrosis was the basis for separating intermediate and high‐grade STS (< 15% necrosis = grade 2; > 15% necrosis = grade 3). The most important prognostic variable was histologic grade, which was highly associated with relative risk of metastasis and fatal outcome (P < .0001). Histologic type of STS was not a significant prognostic variable in predicting metastases. Patients with tumors located on the proximal or middle part of the extremity had a fivefold increased risk of death (P = .02) compared with patients who had STS located more distally. Mitotic activity (P = .0005) and vascular invasion (P = .0034) were also associated with malignant behavior, but histologic grade was the most significant predictor of outcome. Histologic grade of malignancy was based upon a combination of tumor typing and visual estimation of extent of tumor necrosis; using these two features, one can reliably separate low‐grade (i.e., grade 1) from high‐grade STS and also stratify the more aggressive (i.e., grade 2 and 3) tumors. Over the 9.5‐year period of study, the tumor‐related mortality was as follows: grade 1 (1/38), 3%; grade 2 (19/142), 13%; and grade 3 (45/120), 38%.</div>
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Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher‐grade sarcomas

Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher‐grade sarcomas

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri